The Enemy Will Never Make it

Will kinase inhibitors make it as glioblastoma drugs?

Kinase inhibitors have emerged as effective cancer therapeutics in a variety of human cancers. Glioblastoma (GBM), the most common malignant brain tumor in adults, represents a compelling disease for kinase inhibitor therapy because the majority of these tumors harbor genetic alterations that result in aberrant activation of growth factor signaling pathways. Attempts to target the Ras-Phosphati...

Microtechnology in the clinical laboratory: will it solve analytical problems, and when will it make an impact?

The past two decades have seen a phenomenal investment in microtechnology in the biological sciences. But it is often difficult to discern what impact, if any, this diverse technology has had on the clinical laboratory. This difficulty is, in part, due to the almost transparent incorporation of microtechnology in large devices used in the clinical laboratory, or the lack of appreciation of the ...

“it never rains it pours!”

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Rotational atherectomy: you will never regret using it but you often regret not having used it!

My radical prostatectomy: it will never happen to me--but could it?